2026 A Comprehensive Review of Gastrointestinal, Hepatobiliary, and Pancreatic Pathology

This teaching activity has been designed to provide an extensive overview of some of the most common problem areas of diagnostic pathology in the area of gastrointestinal, hepatobiliary, and pancreatic pathology, with particular attention paid to the most common problems encountered by practicing pathologists. The course will provide extensive details of some of the most important diagnostic features which allow pathologists to make accurate diagnoses in each of these areas, as well as how to assess essential diagnostic clues and avoid the most common pitfalls. In each lecture, there is a discussion on the use of appropriate ancillary diagnostic techniques, including both immunohistochemistry and molecular pathology. Some of the lectures include case-based discussions including digital slides.

This teaching activity is primarily intended and designed to educate practicing pathologists.

At the completion of this teaching activity, you should be able to:

• Define the most common diagnostic pitfalls in diagnosing Barrett’s-related dysplasia
• Identify inflammatory patterns of the esophagus, particularly eosinophilic esophagitis
• Discuss the most common GI mesenchymal lesions encountered by practicing pathologists
• Identify the important features in both solid and cystic pancreatic lesions
• Recognize the most common neoplasms of the gallbladder and their mimics
• Define the pattern-based approach to non-inflammatory bowel disease colitis
• Describe the most important clinically relevant aspects to creating a pathology report for colorectal adenocarcinoma
• Review pancreatic ductal adenocarcinoma and inflammatory conditions which can mimic cancer
• Review the most important aspects of reporting biomarkers in gastrointestinal and pancreaticobiliary tumors
• Discuss the most common forms of gastritis and gastropathy seen in biopsy specimens
• Define the most common patterns and causes of injury associated with small bowel malabsorption
• Recognize the most common pitfalls in performing frozen sections of the gastrointestinal tract
• Describe the most recent updates in appendiceal neoplasia nomenclature