Course Description
Gastrointestinal pathology emerged as a subspecialty in the early 1980s, coincident with development of endoscopy and mucosal biopsy for diagnosis and management of patients with gastrointestinal disorders. Since that time, changes in tissue acquisition techniques and ancillary testing have drastically transformed the discipline; current practice bears little resemblance to that of our mentors. The past two decades have seen an explosion in the number and types of biopsy samples pathologists encounter in daily practice. Virtually every part of the tubular gut is now amenable to visualization and sampling, and most liver biopsies are performed by radiologists who utilize small-caliber needles. As a result, pathologists are expected to generate comprehensive and accurate differential diagnoses for a variety of inflammatory and neoplastic disorders based on limited biopsy material. Pathologists must be able to concentrate on key features in order to narrow the differential diagnosis and facilitate patient management.

Learning Objectives
Upon completion of this educational activity, learners will be able to:

• Understand critical concepts in the diagnosis of pancreatic neoplasia
• Explore polyposis, hereditary cancers and Lynch Syndrome
• Formulate an appropriate differential diagnosis for chronic hepatitis and biliary disease
• Distinguish between medication-related injury and other inflammatory conditions of the GI tract
• Explore various neoplasms that affect the gastrointestinal tract, liver and pancreas
• Distinguish lymphoproliferative diseases that affect the gut
• Learn about biomarkers that facilitate accurate diagnosis of GI disease

Topics Covered

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Pancreas Adenocarcinoma and Precursor Lesions Made Simple – Wendy L. Frankel, MD

Mesenchymal Tumors of the GI Tract – Real Estate is Everything – Elizabeth A. Montgomery, MD

How to Recognize Polyposis Syndromes and Hereditary Cancers – Wendy L. Frankel, MD

My Favorite Polyps – Elizabeth A. Montgomery, MD

The Secrets to Working Up Polyposis Syndromes and Hereditary Cancers – Wendy L. Frankel, MD

Esophagitis Is A Pain in the Neck: Reflux, Allergy and Other Things That Make It Hard to Swallow – Joel Greenson, MD

Relief from the Heartburn – Handling Barrett’s Esophagus and Early Esophageal Neoplasia – Elizabeth A. Montgomery, MD

Burning Topics in the Stomach – Focus on Gastritis – Elizabeth A. Montgomery, MD

Biomarker Basics in Upper GI Neoplasia – Wendy L. Frankel, MD

Avoiding Cracks, Potholes and Sinkholes in the Diagnosis of Lynch Syndrome – Wendy L. Frankel, MD

Some Zebras and Rare Birds – Elizabeth A. Montgomery, MD

How Not to Sprue Up A Small Bowel Biopsy – Joel K. Greenson, MD

My Favorite Pancreas Cases – Wendy L. Frankel, MD

Let’s Talk About the Anus – Elizabeth A. Montgomery, MD

Acute Enterocolitis: Bugs and Drugs That Makes Us Miserable – Joel K. Greenson, MD

Chronic Colitis – Joel K. Greenson, MD

The Many Faces of Ischemic Enterocolitis: Clues to a Specific Diagnosis – Rhonda K. Yantiss, MD

Enterocolic Biopsies from Immunosuppressed Patients with Diarrhea – Joel K. Greenson, MD

Adenomas and Other Lumps and Bumps – Rhonda K. Yantiss, MD

Evaluation of Biopsies in Post-Surgical IBD Patients – John A. Hart, MD

Appendiceal Neoplasia: Why Does Something So Small Cause So Much Confusion? – Rhonda K. Yantiss, MD

Is it A Bug, A Drug, or Autoimmune? – Joel K. Greenson, MD

Cancer and Its Mimic in Biopsy Samples – Rhonda K. Yantiss, MD

Lymphoproliferative Diseases of the Gut: A Survival Guide for the General Pathologist (from a General Pathologist) – Lawrence J. Burgart, MD

Colorectal Cancer Staging: What Matters and What Doesn’t – Rhonda K. Yantiss, MD

Common Mistakes, Including Mine: Gastrointestinal Cases – Lawrence J. Burgart, MD

Normal Liver Anatomy, Histology and Patterns of Hepatic Injury – John A. Hart, MD

Yellow and Itching: Cholestasis and Biliary Disease – Lawrence J. Burgart, MD

Steatosis and Steatohepatitis – What Beer Lovers Need to Know – John A. Hart, MD

“Can’t Miss” Pediatric Liver Cases – John A. Hart, MD

Chronic Hepatitis in 2021 – Lawrence J. Burgart, MD

Frozen Sections of Liver Lesions – Rhonda K. Yantiss, MD

Drug Induced Liver Injury: The Bane and Savior for Liver Pathologists – John A. Hart, MD

Challenging Liver Cases, Benign and Malignant – Lawrence J. Burgart, MD

Hepatocellular Carcinoma and Its Greatest Mimics – John A. Hart, MD

Original release date: September 20, 2021